In transplantation experiments using new grafting techniques in cultured mouse embryos, we determine that this phenotype is non-cell-autonomous: wild-type and mutant neural crest cells both migrate in a pattern consistent with the host environment, deviating from their normal pathway only when transplanted into mutant embryos. & Chang, S. The distribution of collapsin-1 mRNA in the developing chick nervous system. Many congenital craniofacial deformations are due to defects in the development of cranial neural crest cells. Transcriptional profiling identified cardiac-crest-specific transcription factors, with single-cell RNA sequencing revealing surprising heterogeneity, including an ectomesenchymal subpopulation within the early migrating population. Development 133 (17): 3359–70.佐藤貴彦ら,"Neural crest determination by co-activation of Pax3 and Zic1 genes Key words: Cranial neural crest (CNC), Calvaria development, Palatogenesis, TGFβtype II receptor signaling Summary Conditional inactivation of Tgfbr2in cranial neural crest causes cleft palate and calvaria defects Yoshihiro Ito1121 Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor.

Gale, E. et al. Lumsden, A., Sprawson, N. & Graham, A. Segmental origin and migration of neural crest cells in the hindbrain region of the chick embryo. Gassmann, M. & Lemke, G. Neuregulins and neuregulin receptors in neural development. Lee, J. E. et al.

Birgbauer, E., Sechrist, J., Bronner-Fraser, M. & Fraser, S. Rhombomeric origin and rostrocaudal reassortment of neural crest cells revealed by intravital microscopy. You can also search for this author in
and JavaScript.Mouse embryos with a loss-of-function mutation in the gene encoding the receptor tyrosine kinase ErbB4 exhibit misprojections of cranial sensory ganglion afferent axons. Lee, Y. M. et al. Kuhlbrodt, K., Herbarth, B., Sock, E., Hermans-Borgmeyer, I.

& Lumsden, A. Homeotic transformation of rhombomere identity after localized Hoxb1 misexpression. なお、英語の "neural crest" からの直訳である「神経冠」という訳語も使用されている。"neural crest"というのは、神経管が閉じた後に背側で移動を開始する神経堤細胞を、トサカ(鶏冠)に見立てたものである(神経管が閉じる以前に神経堤細胞が移動する場合も多い)。 Holder, N. & Klein, R. Eph receptors and ephrins: effectors of morphogenesis. & Tjian, R. Transcription factor Maconochie, M. et al. Tessier-Lavigne, M. & Goodman, C. S. The molecular biology of axon guidance. You can also search for this author in

"Fate of the neural crest in lampreys". COVID-19 is an emerging, rapidly evolving situation. Dixon, M. & Lumsden, A. 2005 Jun 1;282(1):174-82. doi: 10.1016/j.ydbio.2005.03.006.Cell Mol Biol (Noisy-le-grand). & Tam, P. P. L. Cranial paraxial mesoderm and neural crest of the mouse embryo-codistribution in the craniofacial mesenchyme but distinct segregation in the branchial arches. Trainor, P. A., Tan, S. S. & Tam, P. P. L. Cranial paraxial mesoderm-regionalization of cell fate and impact on craniofacial development in mouse embryos. You can also search for this author in Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice Development. ErbB4 signalling events within the hindbrain therefore provide patterning information to cranial paraxial mesenchyme that is essential for the proper migration of neural crest cells.Get time limited or full article access on ReadCube.Lumsden, A. Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase. [2] The endocranium and facial bones of the skull are ultimately derived from crest cells. doi: 10.1371/journal.pcbi.1006569.
"A role for rhoB in the delamination of neural crest cells from the dorsal neural tube".


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